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US 5,330,746 AGranted
Dental varnish composition, and method of use
AssigneesYissum Research Development Company of the Hebrew University of Jerusalem, Petro Products, Inc.
InventorsMichael M. Friedman, Amnon Sintov
Life of this patent
Estimating the term…
Abstract
The invention relates to an oral composition for plaque prevention or tooth hypersensitivity comprising either an antibacterial agent or a hypersensitivity agent embedded in a sustained release carrier such as an acrylic polymer, and a method for the use of said compositions in preventing dental caries, periodontal disease, and tooth hypersensitivity.
Claims24
A sustained release liquid varnish composition which consists essentially of:
- (a) a sustained release acrylic polymer;
- and
- (b) either (i) a bacteriocidal quaternary ammonium salt or (ii) a hypersensitivity agent;
- in a pharmaceutically acceptable vehicle, wherein said sustained release acrylic polymer is selected from the group consisting of (1) an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1, (2) an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2, (3) a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral methacrylic acid esters is 1:20, and (4) a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral methacrylic acid esters is 1:40, and wherein the concentration of the copolymers in the liquid varnish is 9.9% or greater.
1 more element
A sustained release liquid varnish composition which consists essentially of:
- (a) a sustained release acrylic polymer;
- (b) either (i) a bacteriocidal quaternary ammonium salt or (ii) a hypersensitivity agent;
- and
- (c) an agent selected form the group consisting of a flavoring agent, and a coloring agent;
- in a pharmaceutically acceptable vehicle, wherein said sustained release acrylic polymer is selected from the group consisting of (1) an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1, (2) an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2, (3) a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral methacrylic acid esters is 1:20, and (4) a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral methacrylic acid esters is 1:40, and wherein the concentration of the copolymers in the liquid varnish is 9.9% or greater.
2 more elements
A sustained release liquid varnish composition which consists essentially of:
- (a) a sustained release acrylic polymer;
- (b) either (i) a bacteriocidal quaternary ammonium salt or (ii) a hypersensitivity agent;
- and
- (c) a plasticizer;
- in a pharmaceutically acceptable vehicle, wherein said sustained release acrylic polymer is selected from the group consisting of (1) an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1, (2) an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2, (3) a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral methacrylic acid esters is 1:20, and (4) a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral methacrylic acid esters is 1:40, and wherein the concentration of the copolymers in the liquid varnish is 9.9% or greater.
2 more elements
A sustained release liquid varnish composition which consists essentially of:
- (a) a sustained release acrylic polymer;
- (b) either (i) a bacteriocidal quaternary ammonium salt or (ii) a hypersensitivity agent;
- and
- (c) an agent selected from the group consisting of:
- polyethylene glycol and dibutyl phthalate;
- in a pharmaceutically acceptable vehicle, wherein said sustained release acrylic polymer is selected from the group consisting of (1) an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1, (2) an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2, (3) a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral methacrylic acid esters is 1:20, and (4) a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral methacrylic acid esters is 1:40, and wherein the concentration of the copolymers in the liquid varnish is 9.9% or greater.
3 more elements
Dependencies are inferred from the claim text.