Aminosaccharide contrast agents for magnetic resonance images
AssigneeMagnetic Research, Inc.
InventorsWendell A. Gibby, N. Rao Puttagunta
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Abstract
A contrast enhancing agent for magnetic resonance images having a chelating agent, which can be bound to metals having at least one unpaired electron. Examples of such chelating agents include 3,6,9-tris(carboxymethyl)-1, 11-bis(dimethylamine)-3,6,9-triazaundecane; 3,6,9-tris(carboxymethyl)-1, 11-bis(diethanolamino) 3,6,9-triazaundecane; 3,6,9-tris(carboxymethyl)-1, 11-bis(tris(hydroymethyl) aminomethane)-3,6,9-triazaundecane; 3,6-bis(carboxymethyl-1,8-bis(N-carboxymethylglucosamino)-3,6-diazoctane; DTPA-bis(galactosamide), DTPA-Bis(glucosamide), DTPA-Bis(pyridoxamide), and poly-(DTPA-ethylenediamide).
Claims19
A contrast enhancing agent comprising a chelating agent represented by the formula A:
- ##STR10## wherein n=an integer between 1 and 3;
- and R.sub.1 and R.sub.2 are the same or different, independently, and are selected from the group consisting of H, Alkyl (C.sub.1-18), aryl, arylalkyl, mono or polyhydroxyaryl, substituted aryl, substituted hydroxyaryl, alkoxyalkyl, arylalkoxyalkyl, cyclohexyl, mono or polyhydroxy cyclohexyl, furfuryl, tetrahydrofurfuryl, pyranylalkyl, tetrahydropyranylalkyl, and monosaccharide, and wherein at least one of R.sub.1 and R.sub.2 is a monosaccharide.
A contrast enhancing agent comprising a chelating agent represented by the formula A:
- ##STR11## wherein n=3;
- and R.sub.1 and R.sub.2 are the same or different, independently, and are selected from the group consisting of H, alkyl (C.sub.1-18), mono or polyhydroxyalkyl (C.sub.1-18), aryl, arylalkyl, mono or polyhydroxyaryl, substituted aryl, substituted hydroxyaryl, alkoxyalkyl, arylalkoxyalkyt, cyclohexyl, mono or polyhydroxy cyclohexyl, furfuryl, tetrahydrofurfuryl, pyranylalkyl, tetrahydropyranylalkyl, and monosaccharide, and wherein at least one of R.sub.1 and R.sub.2 is a monosaccharide.
A contrast enhancing agent comprising the chelating agent represented by the formula A:
- ##STR12## wherein n=3;
- and R.sub.1 is a monosaccharide;
- and
- R.sub.2 =--CH.sub.2 --COOH.
A contrast enhancing agent comprising the chelating agent represented by the formula A:
- ##STR13## wherein n=1;
- and R.sub.1 =--CH.sub.2 --CO--NH--R.sub.3 ;
- wherein --NH--R.sub.3 is selected from the group consisting of glucosamine, galactosamine, and any aminomonosaccharide;
- and
- R.sub.2 =--CH.sub.2 --COOH.
A contrast enhancing agent comprising the chelating agent represented by the formula A:
- ##STR14## wherein --N--R.sub.1 =a compound selected from the group consisting of glucosamine, galactosamine, and meglumine;
- and R.sub.2 =H or alkyl (C.sub.1-6).
A contrast enhancing agent comprising the chelating agent represented by formula A:
- ##STR15## wherein R.sub.1 =--CH.sub.2 --COOH;
- and R.sub.2 =--CH.sub.2 --CO--NH--R.sub.3, wherein --NH--R.sub.3 is selected from the group consisting of glucosamine, galactosamine, and any aminomonosaccharide.
A magnetic resonance contrast enhancing agent comprising the chelating agent represented by the formula A, ##STR16## wherein N--R.sub.1 =glucosamine or galactosamine.
Dependencies are inferred from the claim text.