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US 5,330,738 AGranted
Technetium-99m complexes for use as radiopharmaceuticals
AssigneeMallinckrodt Medical, Inc.
InventorDennis L. Nosco
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Abstract
The present invention relates to novel technetium-99m complexes and to methods of preparing the complexes. The present invention further relates to a radiopharmaceutical compositions comprising the complexes, to the use of the compositions for examining the renal function, and to a kit for preparing such compositions.
Claims2
A technetium-99 m radiopharmaceutical complex for examining the renal function, said complex having the formula:
- ##STR7## wherein each of the symbols R.sub.1 -R.sub.4 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or hydroxy group or acid group substituted alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or hydroxy group or acid group substituted alkyl group having 0-4 carbon atoms;
- and
- Tc represents technetium-99 m;
- with the provisos that
- (a) at least one of the symbols R.sub.1 -R.sub.4 is ACOOH;
- and
- (b) at most four of the symbols R.sub.1 -R.sub.4 are ACOOH;
- and
- (c) if R.sub.2 or R.sub.3 is CH.sub.2 COOH then one other of R.sub.1 -R.sub.4 must be CH.sub.2 COOH;
- or a pharmaceutically acceptable salt of this complex.
7 more elements
A method of examining the renal function using a radiopharmaceutical complex comprising:
- providing a radiopharmaceutical complex having the formula:
- ##STR8## wherein each of the symbols R.sub.1 -R.sub.4 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted hydroxy group or acid group alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or hydroxy group or acid group substituted alkyl group having 0-4 carbon atoms;
- and
- Tc represents technetium-99 m;
- with the provisos that
- (a) at least one of the symbols R.sub.1 -R.sub.4 is ACOOH;
- and
- (b) at most four of the symbols R.sub.1 -R.sub.4 are ACOOH;
- and (c) if R.sub.2 or R.sub.3 is CH.sub.2 COOH then one other of R.sub.1 -R.sub.4 must be CH.sub.2 COOH;
- or a pharmaceutically acceptable salt of this complex;
- administering said radiopharmaceutical complex to a living being;
- and
- scanning said living being with detection means to detect said administered radiopharmaceutical complex.
10 more elements
Dependencies are inferred from the claim text.