Decarboxylation process
AssigneeAlbemarle Corporation
InventorsKevin J. Theriot, Niomi L. Krzystowczyk, Yueh-Dong Chen, Edward A. Burt, Lawrence H. Shepherd, Jr.
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Abstract
Activated carboxylic acids and esters such as pentafluorobenzoic acid are rapidly decarboxylated in high yields by reacting the acid or ester with an alkanolamine reagent which catalyzes the reaction.
Claims11
A process for the decarboxylation of an activated carboxylic acid or ester, said process comprising reacting said acid or ester with an alkanolamine reagent so as to remove the carboxylic acid or ester group from said acid or ester and replace said carboxylic acid or ester group with hydrogen, said carboxylic acid or ester being continuously or incrementally added to said alkanolamine reagent over a period of time such that said alkanolamine reagent remains in molar excess to said carboxylic acid or ester in the reaction mixture, and the decarboxylated product and carbon dioxide being continually removed as a vapor from the reaction mixture.
The process of claim 8 wherein said aryl carboxylic acid is pentafluorobenzoic acid.
Dependencies are inferred from the claim text.