Carbohydrate-directed cross-linking reagents
AssigneeGenentech, Inc.
InventorsAvi J. Ashkenazi, Steven M. Chamow, Timothy P. Kogan
Life of this patent
Estimating the term…
Abstract
The invention is from the field of heterobifunctional cross-linking reagents. More particularly, the invention concerns cross-linking reagents which combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, thereby allowing coupling of aldehydes to free thiols.
Claims13
A heterobifunctional compound of formula (I) ##STR3## wherein X is an aliphatic hydrocarbon spacer of 6 to about 25 carbon atoms or is ocmposed of an aliphatic hydrocarbon chain and an alicyclic or aromatic moiety having a total numer of 6 to about 25 carbon atoms and has the residue of a reactive group capable of reacting with hydrazide or a hydrazide derivative linked directly to the hydrazide terminus of the molecule, or a salt thereof.
Dependencies are inferred from the claim text.