Quinone derivatives

A quinone derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof:

• ##STR55## wherein A stands for a group represented by the formula:
• ##STR56## wherein R.sup.3, R.sup.4 and R.sup.5 are the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are not simultaneously each a lower alkoxy group, or a group represented by the formula:
• ##STR57## wherein R.sup.3, R.sup.4 and R.sup.5 are the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are not simultaneously each a lower alkoxy group;
• X and Y are the same or different from each other and each stand for a hydroxyl group or a protected hydroxyl group R.sup.1 stands for a 5 or 6 membered nitrogen-containing heteroarylalkyl group selected from the group consisting of a pyridylalkyl group and an imidazolylalkyl group;
• and B stands for a carboxyl group or a protected carboxyl group.

A quinone derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof:

• ##STR58## wherein A stands for a group represented by the formula:
• ##STR59## wherein R.sup.3, R.sup.4 and R.sup.5 are the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are not simultaneously each a lower alkoxy group, or a group represented by the formula:
• ##STR60## wherein R.sup.3, R.sup.4 and R.sup.5 are the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are not simultaneously each a lower alkoxy group;
• X and Y are the same or different from each other and each stand for a hydroxyl group or a protected hydroxyl group;
• R.sup.1 is a pyridylhexyl group or a pyridylpentyl group;
• and B stands for a carboxyl group or a protected carboxyl group.

A quinone derivative or pharmacologically acceptable salt thereof wherein the quinone derivative is selected from the group consisting of the below listed quinone derivatives:

• (E)-3-(2-Methoxy-3,5-dimethyl-1,4-benzoquinon-6-yl)-2-[5-(3-pyridyl)pentyl] -2-propenoic acid
• (E)-3-(2-Methoxy-5,6-dimethyl-1,4-benzoquinon-3-yl)-2-[5-(3-pyridyl)pentyl] -2-propenoic acid
• (E)-3-(2-Methoxy-5,6-dimethyl-1,4-benzoquinon-3-yl)-2-[6-(3-pyridyl)hexyl]- 2-propenoic acid
• (E)-3-(2,4,5-Trimethoxy-3,6-dimethylphenyl)-2-[5-(3-pyridyl)pentyl]-2-prope noic acid
• (E)-3-(2,5-Dihydroxy-4-methoxy-3,6-dimethylphenyl)-2-[5-(3-pyridyl)pentyl]- 2-propenoic acid
• (E)-3-(2,3,5-Trimethoxy-4,6-dimethylphenyl)-2-[5-(3-pyridyl)pentyl]-2-prope noic acid.

A quinone derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof:

• ##STR61## wherein A stands for a group represented by the formula:
• ##STR62## wherein R.sup.3, R.sup.4 and R.sup.5 are the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are not simultaneous each a lower alkoxy group, or a group represented by the formula:
• ##STR63## wherein R.sup.3, R.sup.4 and R.sup.5 are the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are not simultaneously each a lower alkoxy group;
• X and Y are the same or different from each other and each stands for a hydroxyl group or a protected hydroxyl group;
• R.sup.1 is a pyridylalkyl group;
• and B stands for a carboxyl group or a protected carboxyl group.