Antibacterial cephalosporin compounds
AssigneeHoffmann-La Roche Inc.
InventorsHarry A. Albrecht, Dennis D. Keith, Chung-Chen Wei, Manfred Weigele, Roxana Yang
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AssigneeHoffmann-La Roche Inc.
InventorsHarry A. Albrecht, Dennis D. Keith, Chung-Chen Wei, Manfred Weigele, Roxana Yang
Estimating the term…
There are presented antibacterial cephalosporins having broad antimicrobial activity as well as intermediates for their formation, such compounds having the formula ##STR1## wherein R is hydrogen or a carboxylic acid-protecting group; R.sub.1 is a substituted piperazinium group of the formula ##STR2## in which Q represents a substituted quinolinyl or naphthyridinyl group and the piperazine nucleus may be optionally substituted with one or more lower alkyl groups; R.sub.2 is selected from the group consisting of hydrogen, lower alkoxy, lower alkylthio and amido; R.sub.3 is hydrogen or an acyl group; and m is 0, 1 or 2, preferably 0; as well as the corresponding readily hydrolyzable esters, pharmaceutically acceptable salts and hydrates of these compounds.
A compound of formula ##STR41## wherein R is hydrogen or a carboxylic acid-protecting group;
Dependencies are inferred from the claim text.