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US 5,328,997 AGranted
Processes for making proteins having anticoagulant properties
AssigneeMerck & Co., Inc.
InventorsGeorge P. Vlasuk, Lloyd H. Waxman, Victor M. Garsky, Michael P. Neeper
Life of this patent
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Abstract
Proteins which specifically inhibit coagulation Factor Xa. The inhibitors, which do not inhibit Factor VIIa, kallikrein, trypsin, chymotrypsin, thrombin, urokinase, tissue plasminogen activator, plasmin, elastase, Factor XIa or S. aureus V8 protease, are polypeptides of 60 amino acid residues. The inhibitors may be purified from Ornithodoros moubata extract, synthesized, or produced using a recombinant DNA yeast expression system.
Claims4
A gene which is a DNA molecule which codes for a protein having the sequence:
- ##STR6## wherein AA.sup.9 is Arg or Asn
- AA.sup.23 is Arg or Asn
- AA.sup.27 is Arg or Asn, and
- AA.sup.53 is Arg or Asn.
1 more element
Dependencies are inferred from the claim text.