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US 5,328,932 AGranted
Bisamidine derivatives as thrombin inhibitors
AssigneeBristol-Myers Squibb Company
InventorsNeelakantan Balasubramanian, William Teh-Wei Han
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Abstract
The present invention provides new thrombin inhibiting bisamidines derivatives, their pharmaceutically acceptable salts and hydrates, methods for their preparation, pharmaceutical composition, a process for their preparation, and use of the compounds in treatment of thrombosis, ischemia and stroke.
Claims4
A compound having the Formula ##STR44## wherein R.sub.1 is dimethylaminonaphthalenesulfonyl, p-toluene sulfonyl or 2-naphthylene sulfonylglycine;
- R.sup.2 is carboxylic acid, N-substituted amino acid esters wherein the substituents are C.sub.1 -C.sub.5 alkyl;
- and
- n is 1-5;
- and their salts and hydrates thereof.
1 more element
Dependencies are inferred from the claim text.