N-alkylated 1,4-dihydropyridinedicarboxylic acid esters
AssigneeBayer Aktiengesellschaft
InventorsBruno Rosen, Siegfried Zaiss, Hartmund Wollweber, Maarten de Jonge, Hans-Georg Dellweg
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Abstract
N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be prepared either by reaction of aldehydes with acetoacetic esters and amines, optionally with isolation of the corresponding ylidene compounds, or by reaction of aminocrotonic acid esters with ylidene compounds and subsequent alkylation of the NH function. The N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be employed as active compounds in medicaments, in particular as cerebral therapeutics.
Claims11
N-Alkylated 1,4-dihydropyridinedicarboxylic acid esters of the general formula ##STR11## in which R.sup.1 represents trifluoromethoxy, cyano, fluorine, chlorine or trifluoromethyl,
- R.sup.2 represents methyl, ethyl or cyclopropyl,
- with the proviso that R.sup.1 must not represent trifluoromethyl if R.sup.2 denotes methyl;
- or a salt thereof.
An N-alkylated 1,4-dihydropyridinedicarboxylic acid ester of the formula:
- ##STR12## in which R.sub.1 represents trifluoromethyl or trifluoromethoxy;
- and
- R.sub.2 represents methyl, ethyl or cyclopropyl;
- with the proviso that R.sub.1 must not represent trifluoromethyl if R.sub.2 represents methyl;
- or a salt thereof.
Dependencies are inferred from the claim text.