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US 5,328,924 AGranted
Heterocyclic compounds and their use
AssigneeNovo Nordisk A/S
InventorsPer Sauerberg, Preben H. Olesen
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Abstract
The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
Claims10
A compound of formula I ##STR4## wherein Z.sup.1 is oxygen or sulphur;
- Z.sup.2 is sulphur;
- R is R.sup.2, --R.sup.2 --Z.sup.3 --R.sup.3, --R.sup.2 --CO--R.sup.3, --R.sup.2 --CO.sub.2 --R.sup.3, --R.sup.2 --O.sub.2 C--R.sup.3, --R.sup.2 --CONH--R.sup.3 or --R.sup.2 --NHCO--R.sup.3, wherein Z.sup.3 is oxygen or sulphur and R.sup.2 and R.sup.3 independently are straight or branched C.sub.1-15 -alkyl substituted with halogen, OH, CN or one or two phenyl, phenoxy, benzoyl or benzyloxycarbonyl groups wherein each aromatic group is optionally substituted with halogen, CN or C.sub.1-4 -alkyl;
- and
- R.sup.1 is H, straight or branched C.sub.1-5 -alkyl, straight or branched C.sub.2-5 -alkenyl or straight or branched C.sub.2-5 -alkynyl;
- or a pharmaceutically-acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.