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US 5,328,922 AGranted
Indole ureas as 5 ht receptor antagonist
AssigneeBeecham Group Limited
InventorsIan T. Forbes, Roger T. Martin
Life of this patent
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Abstract
A class of compounds identified as N-(1-methyl-1H-indol-5-yl)-(2,3 or 4-pyridyl)ureas, derivatives thereof, methods for their preparation, pharmaceutical compositions containing same and their 5-HT receptor antagonist activity are believed to be of potential use in the treatment of a variety of CNS disorders are described herein.
Claims8
A compound of Formula (I) or a pharmaceutically acceptable salt thereof:
- ##STR12## wherein:
- R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen or C.sub.1-6 alkyl;
- R.sub.4 is hydrogen, C.sub.1-6 alkyl, halogen, hydroxy or NR.sub.8 R.sub.9 where R.sub.8 and
- R.sub.9 are independently hydrogen or C.sub.1-6 alkyl;
- R.sub.5 and R.sub.6 are independently hydrogen or C.sub.1-6 alkyl;
- and
- R.sub.7 is hydrogen, C.sub.1-6 alkyl or halogen;
- and wherein the urea moiety is attached at the 4-, 5- or 6-position of the indole ring.
5 more elements
Dependencies are inferred from the claim text.