Substituted (pyridinylamino)-indoles
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsRichard C. Effland, Joseph T. Klein, Lawrence L. Martin, Gregory M. Shutske, Kevin J. Kapples, John D. Tomer, IV
Life of this patent
Estimating the term…
Abstract
There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorder.
Claims11
A compound of the formula, ##STR48## where R is hydrogen, loweralkyl, carboxyl or loweralkoxycarbonyl;
- R.sub.1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, cycloalkylloweralkyl, loweralkoxyloweralkyl, hydroxyloweralkyl, aminoloweralkyl, mono- or di-loweralkylaminoloweralkyl, formyl, loweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl, mono- or di-aryl-substituted loweralkyl, arylcarbonylloweralkyl, aryloxylloweralkyl, ##STR49## R.sub.2 being hydrogen, loweralkyl or loweralkylcarbonyl;
- --Y.dbd. is --CH.dbd., provided that the hydrogen atom of the group --CH.dbd. may be replaced by either the group R or the group ##STR50## W is hydrogen, halogen, hydroxy, loweralkoxy, arylloweralkoxy, nitro, trifluoromethyl or ##STR51## where R.sub.3 is hydrogen, loweralkyl or arylloweralkyl;
- and R.sub.4 is loweralkyl or arylloweralkyl;
- and
- Z is hydrogen, halogen, loweralkyl, nitro or amino;
- the term cycloalkyl signifying a cycloalkyl group of 3 to 8 carbon atoms, and the term aryl in each occurrence signifying a phenyl group substituted with 0, 1 or 2 substituents each of which being independently loweralkyl, loweralkoxy, loweralkylcarbonyl, halogen, or trifluoromethyl, or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.