Piperidine compounds for treating anoxia, cerebral ischemia migraine or epilepsy
AssigneeNovo Nordisk A/S
InventorsPalle Jakobsen, Anders Kanstrup, Jane M. Lundbeck
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Abstract
The present invention relates to piperidine derivatives of the formula: ##STR1## wherein, R, R.sup.1, R.sup.3, X, and n are defined in the specification, pharmaceutical compositions thereof and methods of treating anoxia, traumatic injury, ischemia, migraine and epilepsy.
Claims10
A compound of formula I ##STR6## wherein R.sup.3 is 3,4-methylenedioxyphenyl, phenyl or naphthyl, each of which may be optionally substituted with halogen, amino, amino which is substituted with one or two C.sub.1-6 -alkyl groups, C.sub.1-6 -alkoxy, cyano, trifluoromethyl, C.sub.2-6 alkenyl, C.sub.1-6 -alkyl, C.sub.3-5 -alkylene, trifluoromethoxy, hydroxy or C.sub.1-4 -alkyl substituted with hydroxy;
- n is 0, 1, 2, 3 or 4;
- R.sup.1 is hydrogen, straight or branched C.sub.1-8 -alkyl, C.sub.1-8 -alkoxy-C.sub.1-8 -alkyl, C.sub.3-8 -cycloalkyl, C.sub.2-6 -alkenyl, C.sub.4-8 -cycloalkylalkyl, acetyl or C.sub.2-6 -alkynyl;
- and
- Y is NR wherein R is hydrogen or C.sub.1-5 -alkyl;
- X is halogen, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl, C.sub.3-8 -cycloalkyl, C.sub.4-8 -cycloalkylalkyl, C.sub.1-6 -alkoxy, cyano, mono- or poly- halogenated C.sub.1-6 -alkyl, hydroxy or hydrogen;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.