Heterocyclic compounds useful for inhibition of renin

A compound of the formula I

• X--W--CR.sup.1 R.sup.2 --CO--Y--NR.sup.3 --CHR.sup.4 --CR.sup.5 --CH.sub.2 --(CR.sup.6 R.sup.7).sub.r --Z--Het I
• wherein
• X is R.sup.8, R.sup.8 --O--C.sub.m H.sub.2m --CO--, R.sup.8 --C.sub.m H.sub.2m --O--CO--, R.sup.8 --C.sub.m H.sub.2m --CO--, R.sup.8 --SO.sub.2 --, R.sup.9 R.sup.10 N--C.sub.m H.sub.2m --CO--, R.sup.11 --NH--C(.dbd.NH)--NH--C.sub.m H.sub.2m --CO--, R.sup.9 OOC--C.sub.m H.sub.2m --CO--, R.sup.9 O.sub.3 S--C.sub.m H.sub.2m --CO--, R.sup.9 --O--(CH.sub.2 CH.sub.2 O).sub.n --C.sub.m H.sub.2m --CO-- or A.sub.3 N.sup..sym. --C.sub.m H.sub.2m --CO--An.sup..crclbar. ;
• W is O, NH, CH.sub.2 or S;
• Y is 0 or 1 amino acid residue selected from Abu, Ada, Ala, .beta.Ala, Arg, Asn, Asp, Bia, Cal, Cys, S--A--Cys, Dab, Gln, Glu, Gly, His, N(im)-A-His, Hph, Ile, Leu, tert.-Leu, Lys, Mal, Met, .alpha.Nal, .beta.Nal, Nbg, Nle, Nva, Orn, Phe, Pia, Pro, Pya, Ser, Thr, Tia, Tic, Tiz, Trp, Tyr or Val;
• Z is O, S, SO or SO.sub.2 ;
• R.sup.1, R.sup.3, R.sup.6, R.sup.7, R.sup.9 and R.sup.10 are each independently H or A;
• R.sup.2, R.sup.4 and R.sup.8 are each independently H, A, Ar, Ar-alkyl, Het, Het-alkyl, unsubstituted cycloalkyl having 3-7 C atoms, cycloalkyl having 3-7 C atoms substituted by A, AO, Hal, or combinations thereof, cycloalkylalkyl having 4-11 C atoms, bicycloalkyl or tricycloalkyl each having 7-14 C atoms, or bicycloalkylalkyl or tricycloalkylalkyl each having 8-18 C atoms;
• R.sup.5 is (H, OH), (H, NH.sub.2) or .dbd.O;
• R.sup.9 R.sup.10 N can also be pyrrolidino, piperidino, morpholino or piperazino group, in each case being unsubstituted or substituted by A, OH, NH.sub.2, NHA, NA.sub.2, NHAc, NH--CO--C.sub.x H.sub.2x --O--R.sup.11, NH--CO--O--C.sub.x H.sub.2x --R.sup.11, hydroxyalkyl, COOH, COOA, CONH.sub.2, aminoalkyl, HAN-alkyl, A.sub.2 N-alkyl, A.sub.3 N.sup..sym. -alkyl An.sup..crclbar., NH--CO--NH.sub.2, NH--CO--NHA, guanidinyl or guanidinylalkyl;
• R.sup.11 is H, A, Ar-alkyl or CN;
• m and x are each 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10;
• n is 1, 2, 3, 4 or 5;
• r is 0, 1, 2 or 3;
• Ar is phenyl which is unsubstituted or substituted by A, OA, Hal, CF.sub.3, OH, NO.sub.2, hydroxyalkyl, NH.sub.2, NHA, NA.sub.2, NHAc, NH--SO.sub.2 --A, SA, SO--A, SO.sub.2 --A, SO.sub.2 NH.sub.2, SO.sub.2 NHA, COOH, COOA, CONH.sub.2, CN, aminoalkyl, HAN-alkyl, A.sub.2 N--alkyl, A.sub.3 N.sup..sym. --alkyl An.sup..crclbar., guanidinylalkyl, or combinations thereof, or is unsubstituted naphthyl;
• Het ia pyridyl, pyrimidinyl, 1,2,4-triazolyl, 5-methyl-1,3,4-thiadiazol-2-yl, 1-methyl-tetrazol-5-yl, 2,5-dihydro-2-furanon-4-yl, thiazolyl, or 1-methyl-4-hydroxymethyl-imidazol-2-yl;
• Hal is F, Cl, Br or I;
• Ac is A--CO--, Ar--CO--, Ar--alkyl--CO-- or A--NH--CO--;
• An.sup..crclbar. is an anion, which can also be absent if, in its place, a carboxyl group contained in the compound of the formula I is in the form of a carboxylate anion;
• -alkyl- is an alkylene group having 1-8 C atoms;
• and
• A is alkyl having 1-8 C atoms;
• wherein one or more --NH--CO-- groups can be replaced by one or more --NA--CO-- groups;
• or a physiologically acceptable salt thereof.