Minoxidil analogs as inhibitors of cell proliferation and lysyl hydroxylase
AssigneeDuke University
InventorsSaood Murad, Sheldon R. Pinnell
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Abstract
The present invention relates to a method of inhibiting cell proliferation and lysyl hydroxylase expression. The method involves the use of minoxidil derivatives. The inhibitory activity of hydroxy derivatives of minoxidil is such that these compounds can be used as selective antifibrotic agents.
Claims13
A method of treating a fibrotic condition comprising administering to a patient suffering from said condition an amount of a minoxidil derivative bearing a hydroxy group on the piperidino moiety thereof sufficient to effect said treatment.
A method of treating abnormal wound healing comprising administering to a patient in need of such treatment an amount of a minoxidil derivative bearing a hydroxy group on the piperidino moiety thereof sufficient to effect said treatment.
A method of controlling excessive collagen crosslink formation comprising administering to a patient suffering from a condition resulting from excessive collagen crosslink formation an amount of a minoxidil derivative bearing a hydroxy group on the piperidino moiety thereof sufficient to effect said control.
Dependencies are inferred from the claim text.