0-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same
AssigneeBiorex Kutato-Fejleszto KFT
InventorsPeter L. Nagy, Bela Balazs, Maria Boross, Jeno Szilbereky, Gizella Zsila, Lajos Abraham, Gyorgy Blasko, Bela Gachalyi, Attila Almasi, Gabor Nemet
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Abstract
Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.
Claims3
Hydroximic acid derivatives of formula (I) ##STR2## and the salts thereof wherein X is selected from the group consisting of fluoro, chloro, bromo and iodo, R.sup.1 and R.sup.2 when taken together with the nitrogen to which these are attached form a heterocyclic ring selected from morpholinyl, piperazinyl or tetrahydroisoquinolinyl groups,
- R.sup.3 is hydrogen, phenyl, naphthyl or optionally substituted with one or more halo or alkoxy,
- R.sup.4 is hydrogen or phenyl,
- R.sup.5 is hydrogen or phenyl,
- m is 0, 1 or 2 and
- n is 0, 1 or 4.
A pharmaceutical composition comprising at least one of the compounds of formula (I) as an active ingredient wherein said composition further comprises an acceptable carrier or diluent.
A method of treating diabetes angiopathy comprising administering compounds of formula (I) in an acceptable carrier.
Dependencies are inferred from the claim text.