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US 5,328,903 AGranted
Composition for solid pharmaceutical preparations containing vitamin D3 derivative
AssigneesTaisho Pharmaceutical Co., Ltd., Sumitomo Pharmaceuticals Company, Limited, Wisconsin Alumni Research Foundation
InventorsKuniaki Ishii, Yumiko Toriumi, Shigeru Itai, Hidefumi Hayashi, Masami Nemoto
Life of this patent
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Abstract
A composition for solid pharmaceutical preparations containing a vitamin D.sub.3 derivative capable of permitting the derivative to be uniformly distributed in the composition while being stabilized. The composition contains an excipient consisting of mannitol and sugar, a degradative agent consisting of hydroxypropyl cellulose, and a binder consisting of polyvinyl pyrrolidone and hydroxypropylmethyl cellulose.
Claims1
A granule consisting essentially of:
- (A) a main component of 26, 26, 26, 27, 27, 27-hexafluoro-1.alpha.25- dihydroxycholecalciferol;
- (B) an excipient of 65 to 95% by weight selected from the group consisting of mannitol and sugar;
- (C) a degradative agent of 5 to 30% by weight of hydroxypropyl cellulose having a low degree of substitution;
- and
- (D) a binder of 1 to 30% by weight selected from the group consisting of polyvinyl pyrrolidone and hydroxymethyl cellulose.
2 more elements
Dependencies are inferred from the claim text.