Anti-thrombotic peptide and pseudopeptide derivatives

A compound of the formula ##STR20## wherein:

• X is H, amidino, ##STR21## Y is --OR.sub.1, ##STR22## a D- or L-amino acid or its corresponding carboximide, a synthetic amino acid of the formula ##STR23## a dipeptide or a dipeptide isostere of the formula ##STR24## R.sub.1 and R.sub.2 are independently H, alkyl, aryl, aralkyl, or allyl;
• R.sub.3 is H, --CO.sub.2 H, --CO.sub.2 R.sub.1, --CONH.sub.2, ##STR25## R.sub.4 and R.sub.5 are independently H, alkyl, cycloalkyl, cycloalkylmethyl, ##STR26## p is 0 to 8;
• R.sub.6 and R.sub.7 form a ring with the nitrogen to which they are attached and are --(CH.sub.2).sub.4 --, (CH.sub.2).sub.5 --, --(CH.sub.2).sub.6 --, --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 NR.sub.1 CH.sub.2 -- or ##STR27## X.sub.2 is H, Cl, Br, F, --OR.sub.1, --NO.sub.2, ##STR28## --SR.sub.1, C.sub.1 -C.sub.5 alkyl, phenyl, --CO.sub.2 R.sub.1, ##STR29## --CF.sub.3 or --NHSO.sub.2 R.sub.1 ;
• V.sub.1 is ##STR30## --(CH.sub.2).sub.n --, --CH.dbd.CH--, --CH.sub.2 --NH--, --CH.sub.2 --O--, --CH.sub.2 --S-- or ##STR31## m is 0, 1 or 2;
• n is 0, 1, 2 or 3;
• and
• p is 0, 1, 2 or 3;
• or
• pharmaceutically acceptable salts thereof.