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AssigneesThe Salk Institute for Biological Studies, The Regents of the University of California
InventorsJaroslav H. Boublik, Jean E. F. Rivier, Marvin R. Brown, Neal A. Scott
Estimating the term…
Human Neuropeptide Y (NPY) has the formula: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro- Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile- Thr-Arg-Gln-Arg -Tyr-NH.sub.2. Porcine and rat NPY have the same sequence except for Leu instead of Met in the 17-position. Porcine PYY is homologous having 11 different residues. NPY analogs and N-terminally-shortened fragments, e.g. NPY(18-36), which contain one or more specific D-isomer substitutions for the naturally occurring residues (as well as pharmaceutically acceptable salts thereof), dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to substantially lower blood pressure over an extended period of time or to counteract hypertension.
A method for lowering the blood pressure of a mammal, which method comprises administering to said mammal an effective amount of a peptide or a nontoxic salt thereof, having one of the following formulae:
A peptide having the formula:
A peptide having the formula:
Dependencies are inferred from the claim text.