Hepatocyte growth factor protease domain variants
AssigneeGenentech, Inc.
InventorsPaul J. Godowski, Natalie A. Lokker, Melanie R. Mark
Life of this patent
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Abstract
The invention concerns hepatocyte growth factor (HGF) variants that compise an amino acid alteration at a site within the protease domain of HGF and retaining substantially full receptor binding affinity of the corresponding wild-type HGF.
Claims21
An isolated nucleotide molecule encoding a hepatocyte growth factor (HGF) variant having an amino acid alteration at a site within the protease domain of HGF, said variant retaining substantially full receptor binding affinity of the corresponding wild-type HGF and being substantially devoid of HGF biological activity.
An isolated nucleotide molecule encoding a human HGF (huHGF) variant having an amino acid alteration at or adjacent to position 692 of wild-type huHGF, said variant retaining substantially full receptor binding affinity of the corresponding wild-type HGF and being substantially devoid of HGF biological activity.
Dependencies are inferred from the claim text.