Tissue irrigation solution
AssigneePeregrine Surgical, Ltd.
InventorsJohn E. Richmond, Bernard E. McCarey
Life of this patent
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Abstract
A tissue irrigation solution containing at least one electrolyte compatible with tissue and a nutrient source including at least one member of the citric acid cycle, deprotinated derivatives and salts thereof which may include a free radical scavenger and/or a wetting agent, said solution being a one-part solution and having a stable shelf-life.
Claims14
A tissue irrigation solution for treating the eye consisting essentially of:
- ______________________________________ sodium 120-160 mM potassium 4-10 mM calcium 0.5-3.0 mM magnesium 0.5-3.0 mM chloride 100-130 mM bicarbonate 20-50 mM sulfate 0.5-3.0 mM at least one member of 2.0-10.0 mM the citric acid cycle selected from the group consisting of citric acid, cis-aconitic acid, isocitric acid, .alpha.-ketoglutaric acid, succinic acid, fumaric acid, malic acid, and oxaloacetic acid, and deprotinated deriva- tives and salts thereof and mixtures of said members, deprotinated derivatives and salts thereof;
- and zwitterionic compound 15-30 mM. ______________________________________
The tissue irrigation solution for treating the eye consisting essentially of:
- ______________________________________ sodium 120-160 mM potassium 4-10 mM calcium 0.5-3.0 mM magnesium 0.5-3.0 mM chloride 100-130 mM bicarbonate 20-50 mM sulfate 0.5-3.0 mM at least one member of 2.0-10.0 mM the citric acid cycle selected from the group consisting of citric acid, cis-aconitic acid, isocitric acid, .alpha.-ketoglutaric acid, succinic acid, fumaric acid, malic acid, and oxaloacetic acid, and deprotinated deriva- tives and salts thereof and mixtures of said members, deprotinated derivatives and salts thereof;
- zwitterionic compound 15-30 mM;
- and ______________________________________
The tissue irrigation solution for treating the eye consisting essentially of:
- ______________________________________ sodium 120-160 mM potassium 4-10 mM calcium 0.5-3.0 mM magnesium 0.5-3.0 mM chloride 100-130 mM bicarbonate 20-50 mM sulfate 0.5-3.0 mM at least one member of 2.0-10.0 mM the citric acid cycle selected from the group consisting of citric acid, cis-aconitic acid, isocitric acid, .alpha.-ketoglutaric acid, succinic acid, fumaric acid, malic acid, and oxaloacetic acid, and deprotinated deriva- tives and salts thereof and mixtures of said members, deprotinated derivatives and salts thereof;
- and zwitterionic compound 15-30 mM an effective amount of a wetting agent;
- and an effective amount of a free radical scavenger. ______________________________________
A tissue irrigation solution for treating the eye consisting essentially of:
- ______________________________________ sodium 149.2 mM potassium 6.3 mM calcium 0.68 mM magnesium 0.76 mM chloride 117.5 mM bicarbonate 39.4 mM sulfate 0.76 mM succinic acid 3.8 mM cysteine 1.1 mM albumin 20 mg % HEPES 20.9 mM ______________________________________
Dependencies are inferred from the claim text.