Method for rendering a substrate surface antithrombogenic and/or anti-infective
AssigneeBecton, Dickinson and Company
InventorsFidelis C. Onwumere, Donald D. Solomon, Stanley C. Wells
Life of this patent
Estimating the term…
Abstract
A shaped medical article of a polymeric substrate is extrusion coated with a composition which includes a bioactive agent dispersed in a matrix polymer. Preferred bioactive agents are temperature sensitive agents which undergo thermal decomposition at a temperature above the processing temperature of the matrix polymer. Preferred matrix polymers have a melting point of about 100.degree. C. or lower.
Claims12
A method for applying a temperature sensitive bioactive agent to the surface of a shaped polymeric substrate comprising:
- (a) combining a matrix polymer having a melting point of about 100.degree. C. or lower with a bioactive agent having a thermal decomposition point above said melting point, said matrix polymer being selected from the group consisting of ethylene acrylic acid copolymer, polycaprolactone, polyethylene adipate, polybutylene adipate, polyethylene azeleate and polyethylene methacrylic acid ionomer;
- (b) melt compounding said matrix polymer and bioactive agent within the temperature range between said melting point and said decomposition point to give a homogeneous composition;
- and
- (c) extrusion coating said composition onto the surface of a shaped polymeric substrate at a temperature within said range.
A method for applying an agent to the surface of a polymeric article comprising:
- a) preparing a homogeneous composition comprising a melt of a matrix polymer and a material selected from the group consisting of a bioactive agent and a quarternary ammonium salt, said matrix polymer being selected from the group consisting of ethylene acrylic acid copolymer, polycaprolactone, polyethylene adipate, polybutylene adipate, polyethylene azeleate and polyethylene methacrylic aid ionomer;
- and
- b) extrusion coating said composition onto a surface of a polymeric article at a temperature at which said material does not undergo any substantial thermal decomposition.
A method for applying a temperature sensitive bioactive agent to the surface of a shaped polymeric substrate comprising:
- a) combining a matrix polymer having a melting point of about 100.degree. C. or lower with a bioactive agent selected from the group consisting of heparin, chlorhexidine, a salt of chlorhexidine, benzalkonium chloride and methyl paraben, said matrix polymer being selected from the group consisting of ethylene acrylic acid copolymer, polycaprolactone, polyethylene adipate, polybutylene adipate, polyethylene azeleate and polyethylene methacrylic acid ionomer;
- b) melt compounding said matrix polymer and bioactive agent within the temperature range between said melting point and the decomposition point of said bioactive agent to give a homogeneous composition;
- and
- c) extrusion coating said composition onto the surface of a shaped polymeric substrate at a temperature within said range.
Dependencies are inferred from the claim text.