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US 5,328,680 AGranted
Contrast media comprising a non-ionic contrast agent with low levels of sodium & calcium ions
AssigneeNycomed Imaging AS
InventorsTorsten Almen, Lars Baath, Per Jynge, Audun N. Oksendal
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Abstract
The physiological acceptability of contrast media, especially media for use in angiography, may be enhanced by inclusion of sub-plasma levels of sodium and calcium and, optionally, potassium and/or magnesium, for example 30 mM Na, 0.15 mM Ca, 0.9 mM K and 0.1 mM Mg.
Claims12
A contrast medium composition comprising a physiologically tolerable aqueous carrier medium with dissolved therein:
- a non-ionic contrast agent;
- a physiologically tolerable sodium compound providing a sodium ion concentration of 15 to 75 mM Na;
- a physiologically tolerable calcium salt providing a calcium ion concentration of 0.05 to 0.8 mM Ca;
- and optionally also at least one salt selected from physiologically tolerable potassium and magnesium salts, the total concentration of said 2 mM K;
- wherein the ratio of sodium to calcium ions is greater than 55.
2 more elements
Dependencies are inferred from the claim text.