Composition and method of use for liposome encapsulated compounds for neutron capture tumor therapy
AssigneeVestar, Inc.
InventorsGary Fujii, Paul G. Schmidt, Ronald C. Gamble
Life of this patent
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Abstract
Liposomes with hyperosmotic concentration of compounds encapsulated therein are targeted to tumors for neutron capture therapy. The compounds have an element with a large neutron capture cross section and an isotope that emits alpha particles when bombarded with neutrons. A method employing such liposomes for neutron capture therapy is also described.
Claims16
Neutron capture therapy agents to deliver a compound to a tumor, comprising small unilamellar liposomes having an average diameter of from about 30 to about 200 nm, said liposomes encapsulating a compound at a concentration of greater than 250 mM, said compound containing an element which has a large neutron cross-section and is capable of forming an isotope which emits an alpha particle from within said liposomes when bombarded with neutrons, which liposomes are stable against leakage and destruction.
A method of neutron capture therapy treatment of a tumor comprising introducing into the bloodstream of a subject neutron capture therapy agents comprising small unilamellar liposomes having an average diameter of from about 30 to 200 nm, said liposomes encapsulating a compound at a concentration of greater than 250 mM, said compound containing an element
- (a) having a large neutron capture cross-section, and
- (b) being capable of forming an isotope which emits an alpha particle from within said liposomes when bombarded with neutrons, which liposomes are stable against leakage and destruction,
- and after a time to enable sufficient accumulation of said isotope in the tumor tissue, subjecting the subject to a source that emits neutrons effective for neutron capture therapy.
Dependencies are inferred from the claim text.