Substituted sulfonamide derivative and a pharmaceutical composition comprising the same

A substituted sulfonamide derivative represented by formula (I) or a pharmaceutically acceptable acid addition salt thereof ##STR29## wherein A represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms;

• G represents a group selected from a methylene group and an alkylene group having 2 to 6 carbon atoms, which are each unsubstituted or each have at least one carbon-bonded hydrogen atom substituted with an alkyl group having 1 to 6 carbon atoms or with a hydroxyl group;
• Q.sup.1 represents an ethylene group which is unsubstituted or has at least one carbon-bonded hydrogen atom substituted with an alkyl group having 1 to 6 carbon atoms;
• Q.sup.2 represents a group selected from an ethylene group and a trimethylene group, which are each unsubstituted or each has at least one carbon-bonded hydrogen atom substituted with an alkyl group having 1 to 6 carbon atoms;
• E represents a group selected from a alkyl group having 1 to 6 carbon atoms, a group represented by formula (II-a) and a group represented by formula (II-b), which are each unsubstituted or each have at least one carbon-bonded hydrogen atom substituted with an alkyl group having 1 to 6 carbon atoms or with a hydroxyl group,
• - G - J - Z (II-a),
• - G - Z (II-b),
• wherein G is as defined above, J represents an oxygen atom, a sulfur atom or a nitrogen atoms, and Z represents an aryl group having 5 to 10 carbon atoms which is unsubstituted or has at least one carbon-bonded hydrogen atom substituted with an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms or a halogen atom, or a pyridyl group, with the proviso that a nitrogen atom of said pyridyl group is not bonded to said G or said J;
• and X represents a group represented by a formula selected from the following formulae:
• ##STR30## wherein R.sup.1 represents a hydrogen atom, a halogen atom or an alkyl group having 1 to 6 carbon atoms, and R.sup.2 represents a hydrogen atoms or a hydroxyl group, with a proviso that when R.sup.2 is a hydroxyl group and bonded to the 2-position of formula (III-a), said group of formula (III-a) is a carbostyril group, with the proviso that when E represents said alkyl group or said group of formula (II-b), X represents said group of formula (III-a).