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US 5,326,861 AGranted
Preparation of organic macrocyclic compounds
AssigneeLever Brothers Company, Division of Conopco, Inc.
InventorsStephen A. Madison, Jean H. Koek, Johan J. W. Eshuis, Ronald P. Potman
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Abstract
An improved process for preparing triazacyclo compounds and, in particular, 1,4,7-tritosyl-1,4,7-triazyacyclononane. The process involves reacting a diethylenetriamine triarylsulphonate with a cyclising agent selected from the group consisting of diaryl sulphonates, dialkyl sulphonates, ethylene dibromide, ethylene dichloride and diacetylglycol in the presence of ultrasound.
Claims1
A method for the preparation of 1,4,7-tritosyl-1,4,7-triazacyclononane which comprises reacting
- i) diethylenetriamine tritosylate and
- ii) a cyclising agent selected from the group consisting of ethylene glycol ditosylate, ethylene glycol dibenzene sulphonate, ethylene dibromide, ethylene dichloride and diacetylglycol
- under alkaline conditions in a reaction medium comprising an organic solvent wherein the cyclising agent is soluble and water, at a temperature within the range of from 45.degree. C. to 90.degree. C. and exposing the reaction medium to ultrasound.
Dependencies are inferred from the claim text.