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AssigneeTakeda Chemical Industries, Ltd.
InventorsHaruo Onda, Akira Arimura, Chiharu Kimura, Chieko Kitada
Estimating the term…
Disclosed are (1) a DNA containing a DNA segment coding for PACAP38; (2) a precursor protein of PACAP38; (3) a transformant containing a DNA having a DNA segment coding for PACAP38; (4) a method for preparing mature PACAP38 comprising cultivating the transformant described in the above (3), producing and accumulating a protein in a culture, and collecting the resulting protein; and (5) a method for preparing the above polypeptide comprising condensing a partial amino acid or a peptide which can constitute the mature PACAP38, with a residual portion, and removing a protective group if a product has the protective group. The DNA is applied to experimental animals to understand their brain functions, which serves to elucidate human brain functions. PACAP38 provides information about growth and maintenance of rat and human brain nerves, and can also be utilized as therapeutic agents for various neuropathy.
A precursor protein comprising an amino acid sequence which corresponds to the following formula:
A sheep PACAP38 precursor protein comprising an amino acid sequence which corresponds to the following formula:
A sheep PACAP38 precursor protein comprising an amino acid sequence which corresponds to the following formula:
A human PACAP38 precursor protein comprising an amino acid sequence which corresponds to the following formula:
A human PACAP38 precursor protein comprising an amino acid sequence which corresponds to the following formula:
A rat PACAP38 precursor protein comprising an amino acid sequence which corresponds to the following formula:
A rat PACAP38 precursor protein comprising an amino acid sequence which corresponds to the following formula:
Dependencies are inferred from the claim text.