Nucleic acid encoding N-acetylmuramidase M1
AssigneeAmgen Inc.
InventorsHenri Lichenstein, Keith Langley, Mark Zukowski
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Abstract
Disclosed are DNA sequences encoding N-acetylmuramidase M1, polypeptide products of recombinant expression of these DNA sequences, peptides whose sequences are based upon the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for the detection and quantitation of such proteins and nucleic acids related thereto, as well as procedures relating to the development of bacteriolytic methods, therapeutic agents, and compositions utilizing N-acetylmuramidase M1.
Claims5
A purified and isolated nucleic acid encoding the expression of a polypeptide having the biological activity of Streptomyces globisporus N-acetylmuramidase M1 described by a nucleotide sequence selected from the group consisting of:
- a) the nucleotide sequence as shown in FIG. 1;
- b) a nucleotide sequence which hybridizes under stringent conditions to the nucleotide sequence defined in (a);
- and
- c) a nucleotide sequence encoding the same polypeptide as encoded by the nucleotide sequences of (a) or (b) by means of degtenerate codons.
Dependencies are inferred from the claim text.