US 5,326,790 A · Administration of skin medications by use of dicarboxylic acids and derivatives

Abstract

The topical administration of therapeutic agents to a variety of disease conditions, both cutaneous and systemic, is enhanced by combining the therapeutic agents with dicarboxylic acids or analogs of such acids, which include mono- and dimercapto derivatives, salts, esters, amides and anhydrides. Preferred dicarboxylic acids are azelaic and dodecanedioic acids and their monoglyceride and sucrose salts. Preferred therapeutic agents are antiinflammatory compounds, antihistamine compounds, antineoplastic compounds, vitamin D and retinoid agents. Specific examples of some of these compounds are 5-fluorouracil, methotrexate, bleomycin, carmustine and nitrogen mustard. The acids and analogs of this invention enhance the penetration capabilities of the therapeutic agents and are thus effective in promoting the therapeutic effect of these agents inside diseased cells, particularly for diseases such as inflammatory skin diseases and premalignant and non-melanoma malignant skin tumors.

Claims14

Dependent claims

A method for administering a therapeutic agent to a subject suffering from a disease controllable thereby, said method comprising administering to said subject a composition comprising:

(a) a therapeutically effective amount of said therapeutic agent, and
(b) a therapeutically effective of a compound selected from the group consisting of dicarboxylic acids having 7 to 13 carbon atoms, and mono- and dimercapto derivatives, salts, monoglyceride esters, sucrose esters, amides and anhydrides thereof.

Dependencies are inferred from the claim text.

Administration of skin medications by use of dicarboxylic acids and derivatives

Life of this patent

Administration of skin medications by use of dicarboxylic acids and derivatives

Life of this patent

Abstract

Claims14