Biological fluid purification system
AssigneeNew York University
InventorsDaniel Meruelo, Gad Lavie
Life of this patent
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Abstract
The present invention provides compositions, articles and methods for inactivating viruses present in whole blood and other body fluids. The method comprises contacting the body fluids with an effective amount of an antiviral compound. Blood bags, vacuum blood tubes, condoms, spermicidal jellies and vaginal lubricants containing effective amounts of the antiviral compounds are also provided.
Claims31
An article of manufacture for holding a biological fluid and including means to inactivate any virus in such fluid, comprising:
- container means for holding a biological fluid which may be contaminated with a virus, and
- an effective amount for inactivating said virus of at least one antiviral compound selected from the group consisting of antiviral effective aromatic polycyclic diones;
- antiviral effective analogs, isomers, homologs and derivatives of said aromatic polycyclic diones;
- physiologically acceptable salts of said diones, analogs, isomers, homologs and derivatives;
- and mixtures of said diones, analogs, isomers, homologs, derivatives and salts, said compound being present in said container means for contacting said fluid when said fluid is introduced into said container means.
An article of manufacture comprising:
- means for retaining a biological fluid;
- and
- an antiviral effective amount for inactivating said virus of at least one antiviral effective compound selected from the group consisting of aromatic polycyclic diones;
- antiviral effective analogs, isomers, homologs and derivatives of said aromatic polycyclic diones;
- physiologically acceptable salts of said diones, analogs, isomers, homologs and derivatives;
- and mixtures of said diones, analogs, isomers, homologs, derivatives and salts, and compound being present in said means to contact said fluid when said fluid is introduced into said retaining means.
An article of manufacture for contacting a biological fluid and including means to inactivate any virus in such fluid, comprising:
- surface means for contacting a biological fluid which may be contaminated with a virus, and
- an effective amount for inactivating said virus of at least one antiviral compound selected from the group consisting of antiviral effective polycyclic aromatic diones;
- antiviral effective analogs, isomers, homologs and derivatives of said diones;
- physiologically acceptable salts of said diones, analogs, isomers, homologs and derivatives;
- and mixtures of said diones, analogs, isomers, homologs, derivatives and salts, said compound being present on or in said article of manufacture to contact said fluid no later than when said fluid contacts said surface means.
In an article of manufacture having surface means for coming into contact with a biological fluid which is infected with a retrovirus, the improvement whereby the infectivity of any retrovirus which comes into contact with said surface means is significantly reduced or completely eliminated, wherein the article of manufacture further includes, in contact with surface means, an effective amount of at least one antiretroviral compound selected from the group consisting of antiviral effective polycyclic diones;
- antiretroviral effective analogs, isomers, homologs and derivatives of said diones;
- physiologically acceptable salts of said diones, analogs, isomers, homologs and derivatives;
- and mixtures of said diones, analogs, homologs, derivatives and salts.
A method for inactivating any virus present in a biological fluid, comprising:
- placing into a container intended to hold the biological fluid, an effective amount for inactivating any virus which may be present in the fluid, of at least one antiviral compound selected from the group consisting of antiviral effective aromatic polycyclic diones;
- antiviral effective analogs, isomers, homologs and derivatives of said aromatic polycyclic diones;
- physiologically acceptable salts of said diones, analogs, isomers, homologs and derivatives;
- and mixtures of said diones, analogs, isomers, homologs and derivatives and salts;
- and
- putting the biological fluid into the container.
A method for significantly reducing the infectivity of any virus which is in a biological fluid, comprising:
- placing in contact with a surface of an article of manufacture intended to come into contact with a biological fluid which may be infected with a virus, an effective amount for significantly reducing the infectivity of any virus which is in the biological fluid of at least one antiviral compound selected from the group consisting of antiviral effective aromatic polycyclic diones;
- antiviral effective analogs, isomers, homologs and derivatives of said aromatic polycyclic diones;
- physiologically acceptable salts of said diones, analogs, isomers, homologs and derivatives;
- and mixtures of said diones, analogs, isomers, homologs, derivatives and salts;
- and
- contacting the biological fluid with said surface.
Dependencies are inferred from the claim text.