Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory activity

A compound having the structure ##STR50## or a pharmaceutically acceptable salt thereof wherein M represents hydrogen, a pharmaceutically acceptable cation, or a pharmaceutically acceptable metabolically cleavable group;

• R is NR.sup.1 R.sup.2 wherein
• R.sup.1 is selected from the group consisting of
• hydrogen,
• hydroxyl,
• alkyl of from one to six carbon atoms,
• hydroxyalkyl of from one to six carbon atoms, and
• alkoxyalkyl in which the alkoxy portion and the alkyl portion each contain, independently, from one to six carbon atoms;
• and
• R.sup.2 is selected from the group consisting of
• hydrogen,
• alkyl of from one to six carbon atoms,
• hydroxyalkyl of from one to six carbon atoms,
• alkoxyalkyl in which the alkoxy and the alkyl portion each contain, independently, from one to six carbon atoms, and
• alkanoyl of from two to eight carbon atoms;
• A is selected from the group consisting of
• (a) cycloalkyl of from three to eight carbon atoms, and
• (b) optionally substituted cycloalkyl of from three to eight carbon atoms,
• wherein the optional substituents on the cycloalkyl groups are selected from the group consisting of
• alkyl of from one to six carbon atoms,
• haloalkyl of from one to six carbon atoms,
• alkoxy of from one to six carbon atoms,
• alkoxyalkyl,
• hydroxy, and
• halogen;
• and
• Y is selected from the group consisting of
• alkylene of from one to six carbon atoms,
• alkenylene of from two to six carbon atoms, and
• cyclopropyl;
• with the proviso that when A is cyclopropyl then Y is not alkylene.