Cycloalkylalkylamines which are sigma-receptor ligands and their application in therapy
AssigneeInstitut de Recherche Jouveinal
InventorsJean-Louis Junien, Alain Calvet, Henri Jacobelli, Francois Roman
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Abstract
New cycloalkylalkylamines which are sigma-receptor ligands of formule (I) ##STR1## in which: R.sub.1 is H or lower alkyl; X and Y are H, OH, lower alkyl, lower alkoxy, halogen or nitrile; V.sub.1 and V.sub.2 together form a double bond attached to an oxygen atom or to a hydroxyimino radical, or are linked as an ethylenedioxy chain; A represents a valency bond, an oxygen atom, a methylene or an ethylene group; m is equal to 0, 1 or 2; n has the value of an integer from 1 to 5. Psychotropic drug which is also useful in gastroenterology.
Claims18
New cycloalkylalkylamines which are sigma-receptor ligands of general formula (I) ##STR18## in which:
- R.sub.1 is H or lower alkyl;
- X and Y, which may be identical or different, are H, OH, lower alkyl, lower alkoxy, halogen or nitrile;
- V.sub.1 and V.sub.2 together form a double bond attached to an oxygen atom or else to a hydroxyimino radical N--OH, or else are linked as an ethylenedioxy chain --O--CH.sub.2 --CH.sub.2 --O--;
- A represents a valency bond, an oxygen atom, a methylene group or alternatively an ethylene group;
- m is equal to 1 or 2;
- n has the value of an integer from 2to 5;
- and their addition salts with pharmaceutically acceptable acids.
Cycloalkylalkylamines of formula (I) which are:
- 2-[2-[(N-cyclobutylmethyl-N-methyl)amino]ethyl]-1-oxo-1,2,3,4-tetrahydronap hthalene and its hydrochloride, and
- 2-[2-[(N-cyclopropylethyl-N-methyl)amino]ethyl]-1-oxo-1,2,3,4,-tetrahydrona phthalene and its hydrochloride.
Medicinal product to combat mainly disorders induced by a derangement of the physiological mechanisms controlled by sigma receptors, in mammals or in man, characterized in that it comprises a cycloalkylalkylamine (I) ##STR19## in which:
- R.sub.1 is H or lower alkyl;
- X and Y, which may be identical or different, are H, OH, lower alkyl, lower alkoxy, halogen or nitrile;
- V.sub.1 and V.sub.2 together form a double bond attached to an oxygen atom or else to a hydroxyimino radical N--OH, or else are linked as an ethylenedioxy chain --O--CH.sub.2 --CH.sub.2 --O--;
- A represents a valency bond, an oxygen atom, a methylene group or alternatively an ethylene group;
- m is equal to 1 or 2;
- n has the value of an integer from 2 to 5;
- and their addition salts with pharmaceutically acceptable acids, with a therapeutically acceptable carrier.
Intermediate of formula (II) ##STR20## in which R.sub.1 is H or lower alkyl;
- X and Y, which may be identical or different, are H, OH, lower alkyl, lower alkoxy, halogen or nitrile;
- A represents a valency bond, an oxygen atom, a methylene group or alternatively an ethylene group;
- m is equal to 0, 1 or 2;
- n has the value of an integer from 1 to 5.
Dependencies are inferred from the claim text.