Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy
AssigneeResearch Corporation Technologies, Inc.
InventorScott F. Rosebrough
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Abstract
The present invention provides compounds which are covalent conjugates of deferoxamine and biotin or derivatives thereof. The subject compounds are capable of binding metal ions and avidin or streptavidin, and accordingly are useful in two-step radioimmunoimaging and radioimmunotherapy. Methods for the synthesis of the deferoxamine-biotin conjugates are also provided by the present invention.
Claims12
A compound having the formula ##STR9##
A compound having the formula ##STR10##
A pharmaceutical composition comprising a compound having the formula ##STR11## and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound having the formula ##STR12## and a pharmaceutically acceptable carrier.
A compartmentalized kit for radioimaging or radiotherapy comprising a first container adapted to contain a deferoxamine-biotin conjugate having the formula ##STR13## and a second container adapted to contain an avidin- or streptavidin-conjugated targeting agent.
A compartmentalized kit for radioimaging or radiotherapy comprising a first container adapted to contain a deferoxamine-biotin conjugate having the formula ##STR14## and a second container adapted to contain an avidin- or streptavidin-conjugated targeting agent.
Dependencies are inferred from the claim text.