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US 5,326,775 AGranted
Benzoxazolinonyl alkylamides
AssigneeAdir et Compagnie
InventorsSaid Yous, Isabelle Lesieur, Patrick Depreux, Daniel H. Caignard, Beatrice Guardiola, Gerard Adam, Pierre Renard
Life of this patent
Estimating the term…
Abstract
Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
Claims15
A compound selected from those formula (I):
- ##STR27## in which:
- A represents oxygen,
- X represents a single bond,
- R represents:
- hydrogen or lower alkyl, and in this case p=1 and B represents --CH.sub.2 --CH.sub.2 --NR.sub.1 --CO--R.sub.2 where R.sub.1 represents hydrogen or linear or branched lower alkyl, and
- R.sub.2 represents:
- hydrogen or,
- a cycloalkyl or linear branched lower alkyl, optionally substituted with halogen or,
- cycloalkyl substituted with linear or branched lower alkyl or,
- phenyl or indolyl or phenyl (lower alkyl) or substituted phenyl or substituted indolyl or substituted phenyl (lower alkyl), or
- a group of the formula:
- ##STR28## G representing linear or branched lower alkyl, R.sub.3 and R.sub.4, which may be identical or different, each represent lower alkyl or hydrogen or phenyl or phenyl (lower alkyl), or R.sub.3 and R.sub.4, together with the nitrogen atom to which they are attached, form a pyrrolidino group optionally substituted with one or more lower alkyl, or oxo, phenyl phenyl (lower alkyl), substituted phenyl or, substituted phenyl (lower alkyl), in the definitions of R.sub.2, R.sub.3 and R.sub.4, the term "substituted" qualifying phenyl and phenyl (lower alkyl) and indoyl meaning that these groups are substituted with one or more radicals chosen from lower alkyl, lower alkoxy, trifluoromethyl, and halogen, or alternatively R.sub.1, with R.sub.2 and the group N-Co, forms a pyrrolidinone system of formula:
- ##STR29## J being lower-alkylene having three carbon atoms, or R represents (CH.sub.2).sub.2 --NR.sub.1 --CO--R.sub.2 with R.sub.1 and R.sub.2 having the same definition as given above, and in which case p equals 0 or 1 and B represents lower alkoxy, and its isomers, epimers and diastereoisomers as well as, its addition salts with a pharmaceutically-acceptable acid or base, lower alkyl and lower alkoxy having 1 to 6 carbon atoms inclusive and cycloalkyl having 3 to 8 carbon atoms inclusive.
10 more elements
Dependencies are inferred from the claim text.