Diaryl compounds for their use
AssigneeByk Gulden Lomberg Chemische Fabrik GmbH
InventorsKurt Klemm, Wolf-Rudiger Ulrich, Dieter Flockerzi
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Abstract
Optically pure diaryl compounds of formula I ##STR1## wherein the substituents and symbols have the meanings given int eh specification are proposed as active ingredients in medicaments for the treatment of tumors.
Claims10
A method of reducing susceptible metastasis and neoplastic growth in a mammal which comprises administering to the mammal a therapeutically-effective amount of an optically-pure antineoplastic compound having only inferior calcium channel blocking activity and of formula I ##STR11## wherein Ar is a 3-nitrophenyl or 2,3-dichlorophenyl;
- R1 is methyl;
- R2 is methyl or amino;
- R3 is methyl or ethyl;
- each of R6, R7, R8 and R9 is hydrogen;
- A is ethylene, propylene or A1-0-A2;
- A1 is ethylene;
- and
- A2 is ethylene;
- or a pharmacologically-acceptable salt thereof.
A medicament composition which is useful for treating susceptible tumor-afflicted mammals, the composition comprising non-toxic, pharmaceutically-acceptable medicinal excipient and an effective amount of an optically-pure antineoplastic compound having only inferior calcium channel blocking activity and of formula I ##STR12## wherein Ar is a 3-nitrophenyl or 2,3-dichlorophenyl;
- R1 is methyl;
- R2 is methyl or amino;
- R3 is methyl or ethyl;
- each of R6, R7, R8 and R9 is hydrogen;
- A is ethylene, propylene or A1-0-A2;
- A1 is ethylene;
- and
- A2 is ethylene;
- or a pharmacologically-acceptable salt thereof.
Dependencies are inferred from the claim text.