4-(2-(4-(2-pyridinyloxy)phenyl)ethoxy)quinazoline and analogues thereof

A compound of the formula (I):

• ##STR18## wherein:
• Het is pyridyl, pyrazinyl, pyrimidinyl, or pyridizinyl, optionally substituted with one or more groups selected from halo, lower alkyl, lower alkoxy, haloalkyl, haloalkoxy, NO.sub.2, CN, and lower alkoxy-carbonyl;
• Z is a single bond connecting a carbon atom of Het to a carbon atom of the phenyl group, CH.sub.2, NH, O, S, --CH.sub.2 O--, or --OCH.sub.2 --;
• m is 4;
• R.sup.1 are independently H, halo, lower alkyl, lower alkoxy, haloalkyl, haloalkoxy, NO.sub.2, CN, lower alkoxy-carbonyl, O-phenyl, or O-substituted phenyl;
• substituted phenyl refers to phenyl substituted with lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, lower alkylthio, halo, hydroxy, NO.sub.2, haloalkyl, haloalkoxy, haloalkylthio, CN, phenyl, O-phenyl, C.sub.1 -C.sub.4 alkanoyloxy, or benzyloxy;
• Y is CH.sub.2, NR.sup.3, or O, where R.sup.3 is selected from H, lower alkyl, lower alkyl-carbonyl, lower alkyl-carbonyloxy, SOq-lower alkyl, SOq-phenyl or substituted phenyl;
• and q is an integer from 0 to 2;
• R.sup.2 are independently H, halo, lower alkyl, lower alkoxy, haloalkyl, haloalkoxy, NO.sub.2, CN, or lower alkoxy-carbonyl;
• or an N-oxide or salt thereof.