Back to results
US 5,326,765 AGranted
2,2,4-trialkyl-1,2-dihydroquinazoline-3-oxides
AssigneeOrtho Pharmaceutical Corporation
InventorsDonald W. Combs, Robert Falotico, Victor Bandurco
Life of this patent
Estimating the term…
Abstract
Novel 2,2,4-trialkyl-1,2-dihydroquinazoline-3-oxides and their synthesis are described. These compounds possess cardiotonic activity, and are useful for the treatment of heart failure.
Claims18
A compound of the formula I:
- ##STR7## where R.sub.1 R.sub.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 hydroxyalkyl, carboethoxyethyl or R.sub.1 and R.sub.2 together form a 5 to 8 membered ring;
- R.sub.3 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- and
- R.sub.4 and R.sub.5 are the same or different and are hydrogen, C.sub.1 .C.sub.6 alkoxy, methylenedioxy, halogen, methylthio or dialkylamino;
- with the proviso that when R.sub.4 and R.sub.5 are both hydrogen, R.sub.1 and R.sub.2 cannot both be methyl;
- with the proviso that when R.sub.4 and R.sub.5 are both H, R.sub.3 is methyl, R.sub.1 and R.sub.2 can not be the combination of H and propyl.
3 more elements
Dependencies are inferred from the claim text.