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AssigneeLudwig Institute for Cancer Research
InventorsMaria Andersson, Gudrun Backstrom, Ulla Engstrom, Carl-Henrik Heldin, Ulf Hellman, Arne stman, Bengt Westermark
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The invention described PDGF modifiers. These are peptides which are derived from wild type PDGF monomers, and function as either agonists or antagonists. Various uses of these are described, as well as recombinant means of production. PDGF-B agonists comprising amino acids 97-180 of the PDGF-B monomer having the cysteines at amino acid residues 124 and 133 substituted, nucleic acid molecules encoding the agonists, plasmids, transformed host cells, and methods for causing receptor dimerization and autophosphorylation in a cell having PDGF-.beta. receptors on its surface comprising administering the PDGF-B agonist form part of the invention.
Isolated platelet derived growth factor agonist which binds to PDGF-.beta. receptor and comprises amino acids 97-180 of PDGF-B monomer with the proviso that residues 124 and 133 are not cysteine.
Method for causing receptor dimerization and autophosphorylation in a cell having PDGF-.beta. receptors on its surface comprising administering to a cultured cell having PDGF-.beta. receptor on its surface an amount of the agonist of claim sufficient to cause receptor dimerization and autophosphorylation in said cell.
Dependencies are inferred from the claim text.