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US 5,326,690 AGranted
Ovarian cancer ascites factor, in isolated form
AssigneeAllelix Biopharmaceuticals Inc.
InventorsYan Xu, Anne E. Goodbody
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Abstract
Herein described is an ovarian cancer activating factor that has been isolated from ovarian cancer ascites fluid. The factor may be utilized in its isolated form in a screening program aimed at identifying inhibitors of factor-mediated ovarian cancer activation, or as a growth supplement useful for culturing ovarian and other cancer cell lines.
Claims1
A screening method useful for identifying compounds capable of inhibiting an ovarian cancer cell factor, which method comprises the steps of:
- (1) incubating (a) a factor which is free of proteins and peptides, which is recoverable from ovarian cancer ascites fluid, and which stimulates intracellular calcium release within ovarian cancer cells, with (b) a candidate inhibitor of said factor, and (c) a factor-responsive cell-line;
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- (2) determining the effect of said candidate inhibitor on the intracellular calcium levels within said factor-responsive cell-line, whereby the inhibitory effect of the candidate inhibitors is revealed.
Dependencies are inferred from the claim text.