Dosage forms comprising polymers comprising different molecular weights
AssigneeAlza Corporation
InventorsJeri D. Wright, Brian L. Barclay, David R. Swanson
Life of this patent
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Abstract
A dosage form is disclosed comprising a wall surrounding a compartment, which comprises a first composition comprising a carboxymethylcellulose and a second composition comprising a higher molecular weight carboxymethylcellulose. The first composition comprises a dosage amount of drug that delivers from the dosage form at a controlled rate over time.
Claims13
A dosage form for the administration of a drug to a patient, the dosage form comprising:
- (a) a first composition comprising 10 ng to 750 mg of drug;
- (b) a second composition for pushing the first composition from the dosage form;
- (c) a wall surrounding the first and second compositions, said wall comprising at least in part a composition permeable to the passage of fluid;
- and,
- (d) at least one exit means in the wall for delivering the drug from the dosage form to the patient;
- and wherein said,
- (e) first composition comprises a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight;
- and said,
- (f) second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000;
- and wherein said
- (g) first and second compositions, when the dosage form is in operation, cooperate to deliver substantially all the drug in the dosage form to the patient over time.
A first composition comprising 10 ng to 750 mg of a drug and a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight;
- a second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000;
- and wherein said first composition and second composition are in bilayer arrangement.
A dosage form for administering drug to a patient in need of therapy wherein, the dosage form comprises:
- (a) a first composition comprising 10 ng to 750 mg of a drug, riboflavin, a surface active agent and a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight;
- (b) a second composition for pushing the first composition from the dosage form comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000;
- and,
- (c) at least one exit means in the wall for delivering the drug from the dosage form to the patient.
A first composition comprising 10 ng to 750 mg of a drug, riboflavin, a surface active agent and a carboxymethylcellulose comprising a 10,000 to 300,000 molecular weight;
- a second composition comprising a carboxymethylcellulose comprising a molecular weight greater than 300,000 to 1,200,000;
- and wherein said first composition and second composition are in bilayer arrangement. X
Dependencies are inferred from the claim text.