Method of tissue-specific delivery

A method of bio-oncotic tissue-specific delivery of therapeutic agents, comprising the steps of:

• (a) furnishing an implantable element that is biodegradable in situ within human tissue, said implantable element defining a series of respectively concentric shells having said therapeutic agents incorporated upon or within each of said shells such that the outermost shell and said agents associated therewith will be delivered earliest while the innermost shell and its agents will be delivered last within said human tissue, said agents to be delivered selected from the group consisting essentially of chemotherapeutics, analgesics, hormones, enzymes, anesthetics, anti-inflammatories, antibiotics, and immunoglobulins, and the material of said biodegradable element selected from the group consisting essentially of processed sheep dermal collagen, Hench's bioglass, fibrinogen, polyimino-carbonates, and polylactic acid;
• (b) integrating into a surface of said element a vaso-inductive agent selected from the group consisting essentially of vascular endothelial growth factor, platelet growth factor, vascular permeability growth factor, fibroblast growth factor, and transforming growth factor beta;
• and
• (c) subcutaneously implanting and securing said element into said tissue,
• whereby, following implantation of said element into said tissue, said vaso-inductive agent will stimulate capillary growth thereby facilitating delivery of said therapeutic agents to said tissue.