Antimicrobial compositions useful for medical applications
OwnerChristopher C. Capelliinventor
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Abstract
Antimicrobial metal-based compositions, which are photostable, non-staining, and which are easily absorbed into lipophilic matrices, contain silver cations, complexed by acyclic polyether polymers through the formation of a "host-guest relationship" where the acyclic polyether is the "host" and the silver cation is the "guest," wherein stabilization of this "host-guest relationship" is accomplished through the use of excess halide anions. The compositions are useful for topical treatment of infections caused by bacteria, fungus and viruses in humans and animals and for treating medical devices and adhesives to impart infection-resistance.
Claims16
An antimicrobial composition consisting essentially of
- (a) a stabilizing acyclic polyether polymer;
- (b) silver ion;
- and
- (c) a stabilizing halide selected from the group consisting of chloride, bromide, and iodide, wherein the ratio of equivalents of said halide to equivalents of said silver ion is greater than 4 to 1, when said halide is chloride;
- is greater than 2.1 to 1, when said halide is bromide;
- and is greater than 1.1 to 1, when said halide is iodide;
- and
- wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight.
A method of treating infection in a mammal, comprising the step of applying to an infected site of said mammal a disinfecting amount of an antimicrobial composition consisting essentially of:
- (a) a stabilizing acyclic polyether polymer;
- (b) silver ion;
- and
- (c) a stabilizing halide selected from the group consisting of chloride, bromide, and iodide, wherein the ratio of equivalents of said halide to equivalents of said silver ion is greater than 4 to 1, when said halide is chloride;
- is greater than 2.1 to 1, when said halide is bromide;
- and is greater than 1.1 to 1, when said halide is iodide;
- and
- wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight.
A method of imparting antimicrobial protection to an object, comprising the step of applying to said object an effective protecting amount of an antimicrobial composition consisting essentially of:
- (a) a stabilizing acyclic polyether polymer;
- (b) silver ion;
- and
- (c) a stabilizing halide selected from the group consisting of chloride, bromide, and iodide, wherein the ratio of equivalents of said halide to equivalents of said silver ion is greater than 4 to 1, when said halide is chloride;
- is greater than 2.1 to 1, when said halide is bromide;
- and is greater than 1.1 to 1, when said halide is iodide;
- and
- wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight.
Dependencies are inferred from the claim text.