Antifungal synergistic combination of enzyme fungicide and non-enzymatic fungicide and use thereof
AssigneeCornell Research Foundation, Inc.
InventorsGary E. Harman, Matteo Lorito, Antonio Di Pietro, Christopher K. Hayes
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Abstract
Antifungal composition comprising synergistic combination of fungal cell wall degrading enzyme selected from the group consisting of chitinolytic enzymes, glucanolytic enzymes and cellulases and non-enzymatic fungicides selected from the group consisting of sterol synthesis inhibiting fungicides (e.g., flusilazole and miconazole) and thiol group inactivating fungicides which are not specific to fungal cell membranes (e.g., captan) are applied in an antifungal effective amount to fungus to be inhibited or to a locus to be protected from said fungus.
Claims14
A liquid composition for inhibiting the germination or growth of a fungus, said composition comprising
- (a) a biologically pure fungal cell wall degrading enzyme selected from the group consisting of endochitinases, chitin 1,4-.beta.-chitobiosidases, .beta.-N-acetylglucosaminidases, and glucan 1,3-.beta.-glucosidases, and
- (b) a non-enzymatic fungicide selected from the group consisting of (i) sterol synthesis inhibiting fungicides and (ii) captan, said non-enzymatic fungicide being present at a concentration providing about 4% to less than 95% inhibition of spore germination when used without (a),
- (a) and (b) being present in a weight ratio of (a) to (b) ranging from 2:1 to 500,000:1 on a biologically pure enzyme basis.
Dependencies are inferred from the claim text.