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AssigneeFidia S.p.A.
InventorsFrancesco Della Valle, Gabriella Calderini, Alessandro Rastrelli, Aurelio Romeo
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It is provided biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., characterised by containing an ordered series of holes of a constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells. Artificial skins obtained thereby and its use in grafts are also provided.
Biocompatible membranes consisting of materials of natural, synthetic or semisynthetic original, and having a thickness of between 10 and 500.mu., which comprise an ordered series of holes of a defined and constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., said membrane enabling in vitro culture of keratinocytes within the holes and on both sides of said membrane.
Artificial skin composed of a biocompatible support membrane consisting of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., which contains an ordered series of holes of a defined and constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., together with autologous or heterologous keratinocyte microcolonies in the active proliferation stage present within said holes and on both sides of said membrane.
Dependencies are inferred from the claim text.