Osteogenic proteins
AssigneeStryker Corporation
InventorsHermann Oppermann, Thangavel Kuberasampath, David C. Rueger, Engin Ozkaynak
Life of this patent
Estimating the term…
Abstract
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data, amino acid compositions, solubility properties, structural features, homologies and various other data characterizing osteogenic proteins, 3) methods of producing osteogenic proteins using recombinant DNA technology, and 4) osteogenically and chondrogenically active synthetic protein constructs.
Claims3
A protein, produced by expression of recombinant DNA in a host cell and substantially free of other contaminating proteins, comprising a pair of polypeptide chains disulfide bonded to form a dimeric species, one of said polypeptide chains of said pair having less than 200 amino acids and a sequence comprising ##STR25## or allelic or species variants thereof, said protein having a conformation capable of inducing bone and cartilage formation in association with a matrix when implanted in a mammal.
Dependencies are inferred from the claim text.