Leukotriene B.sub.4 antagonists

A compound represented by the formula:

• ##STR35## and salts thereof, wherein:
• R.sub.1 is hydrogen;
• R.sub.2 is halo, or --OR"
• R.sub.3 is C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.6 alkanoyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.1 -C.sub.4 alkoxy, hydroxy substituted C.sub.1 -C.sub.3 alkyl, or C.sub.1 -C.sub.4 thioalkyl;
• X and Y are the same or different and are selected individually at each occurrence from:
• --CR'.sub.2 --, --O--, --S--, or --NR'--;
• Z is --CH.sub.2).sub.n, --NR'"-- or phenylene;
• A is a bond or a linear or branched chain C.sub.1 -C.sub.10 alkylidene;
• G is --CH.sub.2 --, ##STR36## and wherein:
• R' is independently selected, at each occurrence, from H and C.sub.1-4 alkyl;
• R" is independently selected, at each occurrence, from H and --CH.sub.2).sub.n --H;
• R'" is independently selected, at each occurrence, from H or C.sub.1 -C.sub.4 alkyl;
• n is selected independently,at each occurrence, and ranges from 1-8;
• m is selected independently, at each occurrence, and ranges from 0-4;
• and
• wherein:
• R.sub.4 is selected from the groups;
• ##STR37## wherein W is a bond, 13 CHR).sub.n, --O[CHR'].sub.n).sub.n, --O--, --S--, or ##STR38## and R.sub.5 is H, C.sub.1 -C.sub.6, linear or branched alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, hydroxy, or, cyano, halo, --N.sub.3, --NR'R'", --CO.sub.2 R'
• R.sub.6 is individually selected, at each occurrence, from H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, phenyl, benzyl, --WR.sub.5, halo, thio (C.sub.1 -C.sub.4 alkyl), hydroxy, or --O-- (C.sub.1 -C.sub.10 alkoxy);
• and
• R.sub.7 and R.sub.8 are both individually selected from H or C.sub.1 -C.sub.3 alkyl;
• and
• halo is --F, --Cl, --Br, or --I;
• and pharmaceutically acceptable salts thereof.