Cyclodextrin/drug complexation
OwnerThorsteinn Loftssoninventor
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Abstract
The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-libile drug, comprising combining from about 0.1 to about 70% (weight/volume) of a cyclodextrin and from about 0.01 to about 5% (weight/volume) of a pharmaceutically acceptable, pharmacologically inactive, water-soluble polymer in an aqueous medium with a lipophilic and/or water-labile drug to form a drug complex, optionally followed by removal of water. Related methods, co-complexes of drug/cyclodextrin/polymer, pharmaceutical compositions and cyclodextrin/polymer complexing agents are also provided.
Claims52
A method for enhancing the complexation of cyclodextrin with a lipophilic and/or water-labile drug, said method comprising combining from about 0.1 to about 70% (weight/volume) of cyclodextrin and from about 0.01 to about 5% (weight/volume) of a pharmaceutically acceptable, pharmacologically inactive, water-soluble polymer and a lipophilic and/or water-labile drug in an aqueous medium, the polymer and cyclodextrin being dissolved in the aqueous medium before the drug is added, the aqueous medium which comprises the polymer and cyclodextrin being maintained at from about 30 to about 150.degree. C. for a period of from about 0.1 to about 100 hours before, during and/or after the drug is added, optionally followed by removal of water.
A method for solubilizing and/or stabilizing a lipophilic and/or water-labile drug in an aqueous medium, said method comprising complexing said drug in an aqueous medium comprising from about 0.1 to about 70% (weight/volume) of cyclodextrin and from about 0.01 to about 5% (weight/volume) of a pharmaceutically acceptable, pharmacologically inactive, water-soluble polymer, the polymer and cyclodextrin being dissolved in the aqueous medium before the drug is added, the aqueous medium which comprises the polymer and cyclodextrin being maintained at from about 30.degree. to about 150.degree. C. for a period of from about 0.1 to about 100 hours before, during and/or after the drug is added.
Dependencies are inferred from the claim text.