Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
AssigneeKabi Pharmacia AB
InventorsJohan W. Stjernschantz, Bahram Resul
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Abstract
This invention relates a method for topical treatment of glaucoma or ocular hypertension by administration of an effective intraocular pressure reducing amount of a prostaglandin derivative of PGA, PGB, PGE and PGF, in which the omega chain contains a ring structure. The invention further relates to compositions comprising said prostaglandin derivatives in an ophthalmologically compatible carrier.
Claims17
A therapeutic composition for topical treatment of ocular hypertension or glaucoma comprising therapeutically effective amount of a PGF.sub.2.alpha. isopropyl ester, containing a ring structure, substituted or unsubstituted, on the omega chain, selected from the group consisting of
- 20-phenyl-PGF.sub.2.alpha. isopropyl ester,
- 20-(4-phenylbutyl)-PGF.sub.2.alpha. isopropyl ester,
- 17-(2-thiophene-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-(3-thiophene-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-methyl-17-phenyl-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-(4-trifluoromethyl phenyl)-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-(4-methylphenyl)-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-(2-methylphenyl)-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-(4-fluorophenyl)-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 20(methylenephenyl)-PGF.sub.2.alpha. -isopropyl ester,
- 17-napthyl-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-cyclohexyl-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-(4-methoxyphenyl)-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 17-(3-methoxyphenyl)-18,19,20-trinor-PGF.sub.2.alpha. -isopropyl ester,
- 15-cyclohexyl-16,17,18,19,20-pentanor-PGF.sub.2.alpha. isopropyl ester.
Dependencies are inferred from the claim text.