Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
AssigneeVirginia Commonwealth University Medical College
InventorsDavid J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
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Abstract
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
Claims9
A composition comprising a narcotic analgesic and at least one nontoxic substance that inhibits the development of tolerance to and/or dependence on the narcotic analgesic, said nontoxic substance being selected from the group consisting of dextromethorphan, dextrorphan, trifluoperazine, N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide, their mixtures and their pharmaceutically acceptable salts.
A method of inhibiting the development of tolerance to and/or dependence on a narcotic analgesic administered to a mammal which is liable to addiction thereto which comprises administering the narcotic analgesic to the mammal before, with or following administration to the mammal of a tolerance-reducing and/or dependence-reducing amount of at least one nontoxic substance that inhibits the development of tolerance to and/or dependence on the narcotic analgesic, said nontoxic substance being selected from the group consisting of dextromethorphan, dextrorphan, trifluoperazine, N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide, their mixtures and their pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.